Abstract Intra-tumoral epigenetic heterogeneity is an indicator of tumor population fitness and Timer Knob Bezel is linked to the deregulation of transcription.However, there is no published computational tool to automate the measurement of intra-tumoral epigenetic allelic heterogeneity.We developed an R/Bioconductor package, epihet, to calculate t
Abstract Background The genus Ehrlichia consists of tick-borne obligatory intracellular bacteria that can cause deadly diseases of medical and agricultural importance.Ehrlichia sp.HF, isolated from Ixodes ovatus ticks in Japan [also referred to as I.ovatus Ehrlichia (IOE) agent], causes acute fatal infection in laboratory mice that resembles acute
A variety of transport options must be utilized to enhance public transportation sustainability.Previous studies have rarely developed quantitative methods for evaluating the performance of transport diversity.Thus, this study proposes measurement indicators to evaluate transport diversity on the basis of biodiversity indicators.For the hierarchy o
BackgroundMany ruminant diseases of viral aetiology can be effectively prevented using appropriate vaccination measures.For diseases such as Rift Valley fever (RVF) the long inter-epizootic periods make routine vaccination programs unfeasible.Coupling RVF prophylaxis with seasonal vaccination programmes by means of multivalent vaccine platforms wou